3-(Trifluoromethyl)aniline → HCID 58168271, compound

HRID 1029202Notes

Reaction equation

HRID 1029202 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[F:17][C:18]([F:27])([F:26])[C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22]>>[F:17][C:18]([F:26])([F:27])[C:19]1[CH:20]=[C:21]([NH:22][C:2]2[CH:16]=[CH:15][C:5]3[C:6](=[O:14])[NH:7][C:8]4[C:13]([C:4]=3[CH:3]=2)=[CH:12][CH:11]=[CH:10][N:9]=4)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168271HCID 58168271, compoundYield 3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (50 mg, 0.22 mmol) and 3-(trifluoromethyl)aniline (0.04 mL, 0.33 mmol) to provide 239 (2 mg, 3% yield) as a brown solid. LC-MS (M+H=356, obsd.=356).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-45a4bd9ff9c9468e85fea63fd1598ca1
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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