Indan-5-amine → HCID 58168265, compound

HRID 1029210Notes

Reaction equation

HRID 1029210 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[CH2:23][CH2:22][CH2:21]2>>[CH2:23]1[C:24]2[C:20](=[CH:19][C:18]([NH:17][C:2]3[CH:16]=[CH:15][C:5]4[C:6](=[O:14])[NH:7][C:8]5[C:13]([C:4]=4[CH:3]=3)=[CH:12][CH:11]=[CH:10][N:9]=5)=[CH:26][CH:25]=2)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 90496Indan-5-amineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168265HCID 58168265, compoundYield 29.1%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (1000 mg, 0.43 mmol) and 5-aminoindan (87 mg; 0.65 mmol) to provide 247 (41 mg, 26% yield) as a brown solid. LC-MS (M+H (parent)=328, obsd.=328).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-d5b20e5a6707484696789be261b58c32
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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