Benzenamine, 3-ethynyl- → HCID 58168341, compound

HRID 1029222Notes

Reaction equation

HRID 1029222 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[C:17]([C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22])#[CH:18]>>[NH2:22][C:21]1[CH:20]=[C:19]([C:17]#[C:18][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 104682Benzenamine, 3-ethynyl-HCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168341HCID 58168341, compoundYield 74.7%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 3-ethynylaniline (0.07 mL, 0.65 mmol) to provide 260 (100 mg, 74% yield) as a brown solid. LC-MS (M+H=312 obsd.=312).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e6664bbb61cd406989f4f3dffdd757d7
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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