HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoroaniline → HCID 69813140, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Reactant | HCID 69810728 | HCID 69810728 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69813140 | HCID 69813140 | 46.1% |
Reaction Steps
299 (18 mg, 0.04 mmol), DIEA (16 mg, 0.12 mmol), BOP-Cl (13 mg, 0.05 mmol), and 3-fluoroaniline (13 mg, 0.12 mmol) were suspended in CH2Cl2 (1 mL), and stirred overnight at room temperature. The crude reaction mixture was purified directly via HP-LC to provide 300 (10 mg, 37% yield) as a solid. LC-MS (M+H=543, obsd.=543).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-96de56ce4ad041c1a84f211396669ed3 |
| Source note | uspto-grants-2014_05 |