3,4-Difluoroaniline → HCID 69815591, compound

HRID 1029244Notes

Reaction equation

HRID 1029244 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([NH:7][C:8]2[CH:17]=[CH:16][N:15]=[C:14]3[C:9]=2[C:10]2[CH:22]=[CH:21][CH:20]=[CH:19][C:11]=2[C:12](=[O:18])[NH:13]3)[N:4]([CH2:23][C:24](NC2C=CC=CC=2)=[O:25])[N:3]=1.[F:33][C:34]1[CH:35]=[C:36]([CH:38]=[CH:39][C:40]=1[F:41])[NH2:37]>>[F:33][C:34]1[CH:35]=[C:36]([NH:37][C:24](=[O:25])[CH2:23][N:4]2[C:5]([NH:7][C:8]3[CH:17]=[CH:16][N:15]=[C:14]4[C:9]=3[C:10]3[CH:22]=[CH:21][CH:20]=[CH:19][C:11]=3[C:12](=[O:18])[NH:13]4)=[CH:6][C:2]([CH3:1])=[N:3]2)[CH:38]=[CH:39][C:40]=1[F:41]

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 69813255HCID 69813255, compound

Product 1

HCID 69815591HCID 69815591, compound

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 300 using the carboxylic acid intermediate from example 308 and 3,4-di-fluoroaniline to provide 309. LC-MS (M+H=461, obsd.=461).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-0b71093edb324c489cace240593f0fde
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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