Aniline → HCID 58168267, compound

HRID 1029249Notes

Reaction equation

HRID 1029249 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:32])[C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:26]=[CH:25][N:24]=[C:23]4[C:18]=3[C:19]3[CH:31]=[CH:30][CH:29]=[CH:28][C:20]=3[C:21](=[O:27])[NH:22]4)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.NC1C=CC=CC=1>>[O:27]=[C:21]1[C:20]2[CH:28]=[CH:29][CH:30]=[CH:31][C:19]=2[C:18]2[C:23](=[N:24][CH:25]=[CH:26][C:17]=2[NH:16][C:13]2[CH:14]=[CH:15][C:10]([C:9]([NH:8][C:5]3[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=3)=[O:32])=[CH:11][CH:12]=2)[NH:22]1

Participants

3

Reactant 2

HCID 6115AnilineHCID 58168140N-(4-Fluorophenyl)-4-(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)benzamide

Product 1

HCID 58168267HCID 58168267, compound

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 300 using the carboxylic acid intermediate from example 316 and aniline to provide 317. LC-MS (M+H=407, obsd.=407).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-52ccd3fd1f3c41438a12e3b0aa6dbb04
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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