HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → HCID 58168037, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(4-Piperidinylamino)benzo[c][1,8]naphthyridin-6(5H)-one | HCID 58168194 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 58168037 | HCID 58168037 | 28.6% |
Reaction Steps
358 (60 mg, 0.20 mmol) and benzaldehyde (0.03 mL, 0.26 mmol) were suspended in DCE (4 mL), and stirred for 2 h at room temperature. NaBH(OAc)3 (130 mg, 0.61 mmol) was added, and the reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched with 1NHCl and the crude material was purified directly via HPLC to provide 361 (22 mg, 28% yield) as a solid. LC-MS (M+H=385, obsd.=385).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-4e782672069b48639edb2f27fe45895c |
| Source note | uspto-grants-2014_05 |