N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamide → 4-Fluoro-N-[4-(9-trifluoromethyl-6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-ylamino)-phenyl]-2-trifluoromethyl-benzamide

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Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 378, method 2 using 1-chloro-9-trifluoromethyl-5H-benzo[c][1,8]naphthyridin-6-one and N-(4-amino-phenyl)-4-fluoro-2-trifluoromethyl-benzamide to provide 404. LC-MS (M+H=561, obsd.=561). 1H NMR (400 MHz, DMSO-d6): δ, 6.96 (d, 1H), 7.18 (d, 2H), 7.54 (m, 2H), 7.76 (m, 2H), 7.78 (d, 1H), 7.97 (d, 1H), 8.10 (d, 1H), 8.27 (s, 1H), 8.99 (s, 1H), 10.25 (s, 1H).

Provenance & Evidence