[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid → HCID 58167980, compound

HRID 1029264Notes

Reaction equation

HRID 1029264 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1I.[F:10][C:11]1[CH:12]=[CH:13][C:14]([C:20](OC)=[O:21])=[C:15](B(O)O)[CH:16]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:3]=1[C:13]1[CH:12]=[C:11]([F:10])[CH:16]=[CH:15][C:14]=1[C:20](=[O:21])[NH:8]2

Participants

3

Reactant 2

HCID 4374269[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acidHCID 229365964-Chloro-3-iodopyridin-2-amine

Product 1

HCID 58167980HCID 58167980, compoundYield 21.3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 1 using 4-chloro-3-iodopyridin-2-amine (1.20 g, 4.72 mmol) and 5-fluoro-2-methoxycarbonylphenylboronic acid (1.03 g, 5.19 mmol) to provide 410 (250 mg, 21% yield) as a solid. LC-MS (M+H=249, obsd.=249).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-4fc0e2d2e2c14e918ad31f629431d5b2
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…