Sodium Hydroxide → HCID 58168164, compound

Participants

Reaction Steps

NaOH (4.2 mL, 1.00 M, 4.18 mmol) was added to a suspension of 423 (200 mg, 0.42 mmol) in THF (5 mL), and stirred overnight at room temperature. The crude reaction mixture was purified directly via HP-LC to provide 434 (17 mg) as a solid. LC-MS (M+H=451, obsd.=451). 1H NMR (400 MHz, DMSO-d6): δ 6.93 (d, 1H), 7.20 (d, 2H), 7.54 (m, 3H), 7.76 (m, 2H), 7.78 (d, 1H), 7.97 (d, 1H), 8.10 (d, 1H), 8.27 (s, 1H), 8.85 (d, 1H), 9.18 (s, 1H), 10.27 (s, 1H).

Provenance & Evidence