1,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)- → HCID 58168138, compound

HRID 1029271Notes

Reaction equation

HRID 1029271 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[CH2:17]([NH:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:24]([CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 660291,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)-HCID 58168298HCID 58168298, compound

Product 1

HCID 58168138HCID 58168138, compoundYield 3.4%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 448 using 6 (200 mg, 0.87 mmol) and N′-benzyl-N,N-dimethylethane-1,2-diamine (0.67 ml, 3.47 mmol) to provide 450 (11 mg, 3% yield) as a white powder. LC-MS (M+H=373, obsd.=373). 1H NMR (400 MHz, DMSO-D6) δ 11.61 (s, 1H), 9.88 (m, 1H), 8.76 (d, J=7.5, 1H), 8.45 (d, J=3.4, 1H), 8.08 (d, J=9.0, 1H), 7.57 (s, 1H), 7.20 (m, 6H), 7.10 (d, J=7.0, 1H), 4.86 (s, 2H), 4.02 (m, 4H), 2.89 (d, J=4.7, 6H).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-314c6500251d475c8f0f29a44d3e84ee
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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