3-(Trifluoromethyl)benzylamine → HCID 44205287, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 448 using 6 (230 mg, 1.0 mmol) and (3-(trifluoro-methyl)phenyl)methanamine (350 mg, 1.00 mmol) to provide 451 (76 mg, 20% yield) as a white powder. LC-MS (M+H=370, obsd.=370). 1H NMR (400 MHz, DMSO-D6) δ 11.51 (s, 1H), 8.59 (d, J=8.1, 1H), 8.42 (dd, J=1.6, 4.7, 1H), 8.00 (d, J=8.8, 1H), 7.70 (m, 2H), 7.60 (d, J=6.9, 2H), 7.41 (d, J=2.1, 1H), 7.25 (dd, J=4.7, 8.0, 1H), 6.97 (dd, J=2.2, 8.8, 1H), 4.63 (s, 2H).

Provenance & Evidence