2,4-Bis(trifluoromethyl)benzyl bromide → HCID 58168202, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 454 using 70 (121 mg, 0.57 mmol) and 1-(bromo-methyl)-2,4-bis(trifluoromethyl)benzene (176 mg, 0.57 mmol) to provide 455 (55 mg, 22% yield) as a white powder. LC-MS (M+H=438, obsd.=438). 1H NMR (400 MHz, DMSO-D6) δ 11.55 (s, 1H), 8.37 (m, 2H), 8.06 (dd, J=7.9, 13.0, 2H), 7.84 (d, J=8.5, 1H), 7.31 (m, 2H), 7.24 (dd, J=4.7, 7.9, 1H), 6.94 (dd, J=2.1, 8.8, 1H), 4.77 (d, J=5.7, 2H).

Provenance & Evidence