1-Benzyl-4-piperidylamine → HCID 58167950, compound

HRID 1029278Notes

Reaction equation

HRID 1029278 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[CH2:17]([N:24]1[CH2:29][CH2:28][CH:27]([NH2:30])[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:24]1[CH2:29][CH2:28][CH:27]([NH:30][C:2]2[CH:16]=[CH:15][C:5]3[C:6](=[O:14])[NH:7][C:8]4[C:13]([C:4]=3[CH:3]=2)=[CH:12][CH:11]=[CH:10][N:9]=4)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 4158521-Benzyl-4-piperidylamineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58167950HCID 58167950, compoundYield 50.7%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 456 using 6 (400 mg, 1.73 mmol) and 1-benzyl-piperidin-4-amine (1.31 mL, 6.94 mmol) to provide 457 (337 mg, 50% yield) as a white powder. LC-MS (M+H=385, obsd.=385).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-be2d7269e4a34fb19e790045883f6b64
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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