反应详情

The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (100 mg, 0.47 mmol) and ethyl 3-bromopropanoate (0.01 mL, 0.57 mmol) to provide 459 (97 mg, 66% yield) as a white powder. LC-MS (M+H=312, obsd.=312). 1H NMR (400 MHz, DMSO-D6) δ 8.54 (dd, J=6.3, 14.0, 1H), 8.03 (d, J=8.7, 1H), 7.29 (m, 2H), 6.88 (d, J=6.8, 1H), 6.17 (s, 1H), 4.68 (t, J=7.5, 2H), 4.01 (q, J=7.1, 2H), 2.63 (dd, J=21.6, 29.0, 4H), 1.10 (t, J=7.1, 3H).

1. customThe title compound was synthesized