2-(Bromomethyl)benzonitrile → HCID 58168102, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (140 mg, 0.66 mmol) and 2-(bromomethyl)benzonitrile (156 mg, 0.80 mmol) to provide 462 (45 mg, 21% yield) as a white powder. LC-MS (M+H=327, obsd.=327). 1H NMR (400 MHz, DMSO-D6) δ 8.56 (dd, J=1.6, 8.0, 1H), 8.47 (dd, J=1.6, 4.7, 1H), 8.06 (d, J=8.7, 1H), 7.87 (dd, J=1.2, 7.7, 1H), 7.47 (m, 1H), 7.41 (m, 1H), 7.40 (d, J=7.7, 1H), 7.36 (dd, J=4.7, 7.9, 1H), 6.98 (d, J=7.9, 1H), 6.91 (dd, J=2.0, 8.7, 1H), 6.25 (s, 1H), 5.81 (s, 2H).

Provenance & Evidence