Benzonitrile, 3-(bromomethyl)- → HCID 58168231, compound

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Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (141 mg, 0.67 mmol) and 3-(bromo methyl)benzonitrile (157 mg, 0.80 mmol) to provide 463 (35 mg, 16% yield) as a white powder. LC-MS (M+H=327, obsd.=327). 1H NMR (400 MHz, DMSO-D6) δ 8.46 (m, 2H), 8.06 (d, J=8.6, 1H), 7.73 (s, 1H), 7.69 (d, J=7.6, 1H), 7.57 (d, J=8.0, 1H), 7.48 (t, J=7.8, 1H), 7.42 (d, J=2.0, 1H), 7.36 (dd, J=4.7, 7.8, 1H), 6.90 (dd, J=2.1, 8.7, 1H), 6.22 (s, 2H), 5.69 (s, 2H).

Provenance & Evidence