2-Chloro-6-fluorobenzyl bromide → HCID 58168209, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (149 mg, 0.70 mmol) and 2-(bromo-methyl)-1-chloro-3-fluorobenzene (189 mg, 0.85 mmol) to provide 471 (14 mg, 6% yield) as a white powder. LC-MS (M+H=355, obsd.=355). 1H NMR (400 MHz, DMSO-D6) δ 11.53 (s, 1H), 8.64 (m, 1H), 8.45 (s, 1H), 8.01 (s, 1H), 7.99 (s, 1H), 7.50 (s, 2H), 7.43 (s, 2H), 7.30 (s, 1H), 6.97 (s, 1H), 4.55 (s, 2H).

Provenance & Evidence