Sodium Hydroxide → HCID 58168033, compound

Participants

Reaction Conditions

Reaction Steps

463 (48 mg, 0.15 mmol) and NaOH (1M, aqueous, 0.73 mL) were suspended in N,N-dimethylacetamide (2 mL), and stirred for 16 h at 100° C. The reaction mixture was purified directly via prep-LC-MS to provide 473 (24 mg, 47% yield) as a white powder. LC-MS (M+H=345, obsd.=345). 1H NMR (400 MHz, DMSO-D6) δ 8.55 (d, J=7.8, 1H), 8.50 (d, J=4.3, 1H), 8.06 (d, J=8.5, 1H), 7.94 (s, 1H), 7.74 (s, 1H), 7.69 (d, J=7.5, 1H), 7.43 (s, 1H), 7.35 (dd, J=7.2, 14.4, 2H), 6.91 (d, J=8.8, 1H), 5.70 (s, 2H).

Provenance & Evidence