2-(2-Aminoethyl)-1-methylpyrrolidine → HCID 58168371, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 456 using 6 (100 mg, 0.43 mmol) and 2-(1-methyl-pyrrolidin-2-yl)ethanamine (0.25 mL, 1.73 mmol) to provide 475 (35 mg, 25% yield) as a white powder. LC-MS (M+H=322, obsd.=322). 1H NMR (400 MHz, DMSO-D6) δ 11.47 (s, 1H), 8.65 (d, J=8.1, 1H), 8.43 (d, J=4.7, 1H), 7.99 (d, J=8.8, 1H), 7.18 (m, 2H), 6.89 (d, J=8.8, 1H), 6.65 (s, 1H), 3.24 (s, 2H), 2.98 (m, 1H), 2.25 (d, J=1.4, 3H), 2.02 (m, 2H), 1.97 (s, 2H), 1.66 (s, 2H), 1.52 (s, 2H).

Provenance & Evidence