2-(3,5-dimethylpiperidin-1-yl)ethanamine → HCID 58168018, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 456 using 6 (171 mg, 0.74 mmol) and 2-(3,5-dimethylpiperidin-1-yl)ethanamine (464 mg, 2.97 mmol) to provide 478 (23 mg, 9% yield) as a white powder. LC-MS (M+H=351, obsd.=351). 1H NMR (400 MHz, DMSO-D6) δ 11.58 (s, 1H), 9.48 (s, 1H), 8.73 (d, J=6.7, 1H), 8.46 (dd, J=1.6, 4.7, 1H), 8.06 (d, J=8.7, 1H), 7.42 (d, J=2.1, 1H), 7.29 (dd, J=4.7, 7.9, 1H), 6.96 (dd, J=2.1, 8.8, 1H), 3.70 (s, 2H), 3.52 (d, J=11.1, 2H), 3.30 (d, J=5.3, 2H), 2.56 (dt, J=8.1, 16.4, 2H), 1.89 (s, 2H), 1.77 (d, J=13.0, 1H), 0.91 (t, J=8.4, 6H), 0.80 (dd, J=12.3, 24.8, 1H).

Provenance & Evidence