1-(3-Aminopropyl)-2-pyrrolidinone → HCID 58168032, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 456 using 6 (160 mg, 0.69 mmol) and 1-(3-aminopropyl)pyrrolidin-2-one (395 mg, 2.78 mmol) to provide 479 (15 mg, 7% yield) as a white powder. LC-MS (M+H=337, obsd.=337). 1H NMR (400 MHz, DMSO-D6) δ 11.47 (s, 1H), 8.67 (d, J=7.7, 1H), 8.43 (d, J=3.2, 1H), 7.99 (d, J=8.8, 1H), 7.19 (m, 2H), 6.90 (dd, J=1.9, 8.7, 1H), 6.64 (s, 1H), 3.27 (m, 4H), 3.24 (s, 2H), 2.23 (t, J=8.0, 2H), 1.87 (m, 2H), 1.73 (m, 2H).

Provenance & Evidence