HCID 9995294, compound → N-({4-[(5-Bromopyrimidin-2-yl)oxy]-3-methylphenyl}carbamoyl)-2-(dimethylamino)benzene-1-carboximidic acid

HRID 1029391Notes

Reaction equation

HRID 1029391 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][C:10]=2[CH3:18])=[N:6][CH:7]=1.[CH3:19][N:20]([CH3:30])[C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([NH2:25])=[O:24]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[N:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:25][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[N:20]([CH3:19])[CH3:30])=[O:17])=[CH:11][C:10]=2[CH3:18])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 9995294HCID 9995294, compoundHCID 224780682-(Dimethylamino)benzamide

Product 1

HCID 368697N-({4-[(5-Bromopyrimidin-2-yl)oxy]-3-methylphenyl}carbamoyl)-2-(dimethylamino)benzene-1-carboximidic acid

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of a mixture comprising 3.73 g of 4-(5-bromo-2-pyrimidinyloxy)-3-methylphenyl isocyanate, 2.0 g of 2-(dimethylamino)benzamide and 45 ml of toluene, was reacted under reflux for 4 hours.

Workup

  1. temperatureunder reflux for 4 hours

Sources & evidence

ORD record
ord-1a34c161503a4d2fb105bdb5c5af3dc3
Source dataset
uspto-grants-1992_04
Patent number
US05102884

Reaction notes

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