HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzylpiperidine → HCID 14053690, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzylpiperidine | HCID 31738 | — |
| Reactant | Methyl 5-oxo-L-prolinate | HCID 78646 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 14053690 | HCID 14053690 | 83.7% |
Reaction Steps
Methyl pyroglutamate (4.3 g) and 7.9 g of 4-benzylpiperidine were dissolved in 20 ml of toluene and the mixture was heated to reflux with stirring for 24 hours. The reaction solution was treated with a silica gel column chromatography to give 7.2 g of the product which was recrystallized from diethyl ether to afford 6.5 g of desired product, m.p. 160°-161° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102882 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-2a8c513531f841418645acb6b1c2df89 |
| Source note | uspto-grants-1992_04 |