Benzyl Bromide → HCID 44278819, compound

Participants

Reaction Steps

At 0° C., 50% NaH in oil (37 mg) was added portionwise to a solution of 1-hydroxy-1-(4-2(-quinolinylmethoxy)phenyl)ethanol (Step 1) (104 mg) and benzyl bromide (92 mg). Stirring was continued for 18 h and the reaction was quenched with 25% aqueous NH4OAc. The product was extracted with EtOAc, dried over MgSO4 and purified by flash chromatography on silica gel using EtOAc:hexane (1:4) to give the title compound as an oil.

Provenance & Evidence