Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thioglycolic Acid | HCID 1133 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | HCID 44278819 | HCID 44278819 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19900352 | HCID 19900352 | — |
Reaction Steps
To a mixture of the ether (151 mg) (Step 2) and thioglycolic acid (31 μL) in CH2Cl2 at 0° C. was added BF3 /OEt2 (117 μL) dropwise. The mixture was stirred at 0° C. for 1 h and poured onto 25% aqueous NH4OAc, extracted with CH2Cl2 and the organic phase was dried and evaporated. Chromatography on silica gel using ethyl acetate/hexane containing 0.1% AcOH afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05102881 |
|---|
| Source dataset | uspto-grants-1992_04 |
|---|
| ORD ID | ord-7e599eb3c76b4967a3ecfb34826cfafd |
|---|
| Source note | uspto-grants-1992_04 |
|---|
