反应详情

温度

80 °C

A mixture of the alcohol of Step 3 (138 mg), methyl hydroxyacetate (80 μL), dry fused ZnCl2 (82 mg) in 1,2-dichloroethane (5 mL) was heated to 80° C. for an hour. The title compound was extracted with EtOAc, dried over Na2SO4 and purified by flash chromatography on silica using EtOAc:toluene 5:95 and 7.5:92.5. (For reference, see J. Org. Chem., 52 3917 (1987)).

1. dry with materialdry fused ZnCl2 (82 mg) in 1,2-dichloroethane (5 mL)
2. extractionThe title compound was extracted with EtOAc
3. dry with materialdried over Na2SO4
4. custompurified by flash chromatography on silica