HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetic Acid → HCID 19900409, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetic Acid | HCID 999 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19900409 | HCID 19900409 | 68.3% |
Reaction Steps
The procedure is as in Example 1, but starting with 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (4.95 g) in anhydrous dimethylformamide (60 cc), phenylacetic acid (2.05 g) and 1,8-diazabicyclo[5.4.0]-undec-7-ene (2.25 g). After recrystallization in ethyl acetate, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl phenylacetate (4.4 g), m.p. 222°-224° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-402ca640bef442518131b0c02bd40a0d |
| Source note | uspto-grants-1992_04 |