HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidone carboxylic acid → HCID 86745625, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidone carboxylic acid | HCID 499 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86745625 | HCID 86745625 | 69.4% |
Reaction Steps
The procedure is as in Example 1, but starting with 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (9.9 g) in anhydrous dimethylformamide (100 cc), DL-pyroglutamic acid (3.9 g) and 1,8-diazabicyclo[5.4.0]-undec-7ene (4.6 g). After recrystallization in dimethylformamide, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-oxo-2-pyrrolidinecarboxylate (8.8 g), m.p. 255° C. (decomposition), is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-a7ca0eb02a0b4f7ab1ba22dfee084a7d |
| Source note | uspto-grants-1992_04 |