HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Piperidin-1-yl)butanoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Methylpiperidine-3-carboxylic acid hydrochloride | HCID 12514711 | — |
| Reactant | Ethyl 4-(piperidin-1-yl)butanoate | HCID 14044356 | — |
| Product | 4-(Piperidin-1-yl)butanoic acid hydrochloride | HCID 13172081 | — |
Reaction Steps
4-Piperidinobutyric acid hydrochloride may be obtained by working according to the method described in Example 4 for the preparation of 1-methyl-3-piperidinecarboxylic acid hydrochloride, but starting with ethyl 4-piperidinobutyrate (19.9 g) and 6N aqueous hydrochloric acid solution (66.5 cc), and by heating for 24 hours under reflux. 4-Piperidinobutyric acid hydrochloride (16.3 g), m.p. 190° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-1256304c21b642c9b4ca25f5069ae778 |
| Source note | uspto-grants-1992_04 |