HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyryl chloride → HCID 57243056, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyryl chloride | HCID 8855 | — |
| Reactant | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-hydroxyisoindolin-1-one | HCID 19900408 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57243056 | HCID 57243056 | 43.4% |
Reaction Steps
The procedure is as in Example 30, but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (6.4 g) in methylene chloride (320 cc), pyridine (48 cc) and butyryl chloride (12.8 g). After one recrystallization in isopropyl ether followed by two recrystallizations in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl butyrate (3.4 g), m.p. 140° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-419274cd2fb04fb8af1eaf5e8a43f6d1 |
| Source note | uspto-grants-1992_04 |