Formic Acid → HCID 54086924, compound

Participants

Reaction Steps

A solution of 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanoic acid hydrazide (0.70 g, 2.16 mmol) in 96% formic acid (5.6 mL) is stirred overnight. The reaction mixture is concentrated in vacuo, diluted with ethyl acetate and washed once with a saturated solution of sodium bicarbonate, twice with water, and once with brine. Drying the organic phase over magnesium sulfate and evaporation gives an oil which is crystallized from ethyl acetate/hexane to afford 0.68 g (89%) of 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanoic acid 2-formylhydrazide, mp 158.0°-159.0° C.

Provenance & Evidence