Morpholine → HCID 19012207, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-Chloro-6-methyl-8-propylpurine (from Step 1 of Example 32) (0.1 g, 0.47 mmol) in morpholine (2 ml) was placed in a steel-bomb, and the mixture was heated at 122° C. for 18 hours. The reaction was cooled, and the mixture was concentrated in vacuo. The residue was dissolved in CHCl3 (2 ml) and was purified by flash-chromatography on silica-gel using 5% MeOH in CHCl3 giving the titled compound as an amorphous solid (0.1 g, 87%). NMR (CDCl3): δ1.03 (t, J=8 Hz,3H), 1.8 (q, J=8 Hz, 2H), 2.65 (s, 3H), 2.82 (t, J=8 Hz, 2H), 3.8 (s, 8H). FAB-MS: m/e 262 (M+H).

Provenance & Evidence