Hydrochloric Acid → 3,4-Morpholinedicarboxylic acid, 4-(2-propenyl) ester, (S)-

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Reaction Steps

A solution of ethyl (3S)-4-allyloxycarbonylmorpholine-3-carboxylate (5.90 g) in a mixture of ethanol (15 ml) and 4N aqueous sodium hydroxide (15 ml) was stirred at 30°-40° C. for one hour. Ethanol was evaporated to give an aqueous solution. The aqueous solution was adjusted to pH 2 with concentrated hydrochloric acid, extracted with ethyl acetate (100 ml), dried over magnesium sulfate, and evaporated under reduced pressure to give (3S)-4-allyloxycarbonylmorpholine-3-carboxylic acid (5.24 g) as a syrup.

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