HCID 14988293, compound → HCID 18960815, compound

Participants

Reaction Steps

To 0.3 g of 10% Pd/C in 10 ml of absolute ethanol was added 5-phenylmethoxy-1-(propyl-4-pyridinylamino)-1H-indole (3.0 g) in 240 ml of ethanol and this was hydrogenated on a Parr apparatus for 48 hours at 50° C. and 50 psig H2. The reaction mixture was then filtered and the filtrate concentrated to yield an oil (2.2 g), which was eluted with 5% methanol/dichloromethane on a silica gel column via HPLC. The desired fractions were concentrated to yield a solid (1.8 g) which was recrystallized from methanol/ether (1:1) to yield a solid 1.6 g, m.p. 214°-216° C.

Provenance & Evidence