Potassium Carbonate → HCID 54516609, compound

Participants

Reaction Steps

To 2.5 g of 1-(propyl-4-pyridinylamino)-1H-indol-5-ol in 30 ml of tetrahydrofuran was added potassium carbonate (milled, 1.3 g) followed by methyl isocyanate (0.56 ml). The reaction was allowed to proceed for half an hour. The reaction mixture was then filtered and the filtrate concentrated to yield a solid (2.9 g) which was eluted with 5% methanol in dichloromethane on a silica gel column via HPLC. The desired fractions were concentrated to yield a solid (2.7 g) which was recrystallized from isopropyl ether to yield a solid 1.8 g, m.p. 158°-159° C.

Provenance & Evidence