Potassium Carbonate → HCID 53867360, compound

Participants

Reaction Steps

To a solution of 1-(propyl-4-pyridinylamino)-1H-indol-5-ol (2.1 g) in 50 ml of tetrahydrofuran was added potassium carbonate (milled, 1.3 g). Then propyl isocyanate (0.67 g) was added and the reaction mixture was stirred for 2 hours. The mixture was filtered and the filtrate was concentrated to yield an oil (2.8 g), which was eluted with 5% methanol/dichloromethane on a silica gel column via HPLC. The desired fractions were concentrated to yield an oil which solidified on standing (2.5 g), m.p. 120°-122° C.

Provenance & Evidence