Potassium Carbonate → HCID 54145909, compound

Participants

Reaction Steps

To a solution of 1-(propyl-4-pyridinylamino)-1H-indol-5-ol (2.1 g) in 50 ml of tetrahydrofuran was added potassium carbonate (milled, 1.3 g). Then isopropyl isocyanate (0.67 g) was added and the reaction mixture was stirred for 4 hours. The mixture was filtered and the filtrate was concentrated to yield a solid (3.2 g), which was eluted with 5% methanol/dichloromethane on a silica gel column via HPLC. The desired fractions were concentrated to yield an oil which solidified on standing (2.75 g), m.p. 131°-133° C.

Provenance & Evidence