Potassium Carbonate → HCID 67618171, compound

Participants

Reaction Steps

Benzyl isocyanate (2 g) was added to a solution of 1-(propyl-4-pyridinylamino)-1H-indol-5-ol (3.3 g) in 75 mL tetrahydrofuran containing potassium carbonate (milled, 3 g). After stirring twenty hours at ambient temperature, the mixture was filtered and the filtrate was concentrated. The residue was eluted through silica with ethyl acetate via flash column chromatography to yield 5 g of the product as a solid, m.p. 156°-158° C. The product was recrystallized from acetonitrile to yield 3.8 g of crystals, m.p. 162°-164° C.

Provenance & Evidence