反应详情

In a 500 ml Parr hydrogenation bottle, 10% Pd/C (1.0 g) was suspended in 50 ml ethanol, and to this was added a solution of 1-(3-fluoro-4-pyridinylamino)-5-phenylmethoxy-1H-indole (5.0 g) in 200 ml ethanol. The mixture was shaken at 50° C. under 50 psi hydrogen gas for two hours. After cooling, the mixture was filtered, and the filtrate was concentrated to give an oil (5.0 g) which was eluted on a silica gel column with ethyl acetate/dichloromethane (1:1) via HPLC. The desired fractions were combined and concentrated to give a crystalline solid, 3.5 g, m.p. 70°-73° C.

1. temperatureAfter cooling
2. filtrationthe mixture was filtered
3. concentrationthe filtrate was concentrated