反应详情

3-Methyl-5-phenylmethoxy-1-(4-pyridinylamino)-1H-indole (2.20 g) was subjected to hydrogenolysis in absolute ethanol (80 ml) with 10% Pd-C (0.26 g) at 50 psig hydrogen at 50° C. for 2 hours. The catalyst was removed by filtration through a pad of celite and the solids washed with methanol. Concentration and recrystallization from methanol afforded 0.50 g of highly crystalline product, m.p. 239°-241° C. (dec.).

1. customThe catalyst was removed by filtration through a pad of celite
2. washthe solids washed with methanol
3. concentrationConcentration and recrystallization from methanol
4. customafforded 0.50 g of highly crystalline product, m.p. 239°-241° C. (dec.)