HCID 70147593, compound → HCID 70146441, compound

Participants

Reaction Steps

The benzyl group of 1-[(3-fluoro-4-pyridinyl)propylamino]-3-methyl-5-(phenylmethoxy)-1H-indole (15.82 g) was cleaved in a Parr hydrogenation apparatus in absolute ethanol (200 ml) over 10% Pd-C (1.58 g) at 50 psig and 50° C. for 7.5 hours. The catalyst was removed by filtration through a pad of celite and the solids washed with absolute ethanol. The combined filtrate was concentrated and the product purified via preparative HPLC (silica gel, 3:1 dichloromethane/EtOAc) affording 5.0 g of the desired product as an oil. Addition of EtOAc solidified the product which was recrystallized from EtOAc to give a solid, m.p. 157°-160° C.

Provenance & Evidence