反应详情

Using a similar nitration procedure to that described in Example 9, but starring from acid (C) and using isobutyl nitrate in place of isoamyl nitrate, there was obtained 2-t-butyl-5,5-dimethyl- 2-[2-(nitromethylthio)thien-5-yl]-1,3-dioxane (D) as an oil, in 47% yield; NMR: 0.6(s, 3H), 0.96(s, 9H), 1.2(s, 3H), 3.36(dd, 2H), 3.55(d, 2H), 5.32(s, 2H), 6.82(d, 1H), 7.22(d, 1H); m/e (chemical ionisation) 346 (M+H)+.