Benzylamine → HCID 19901141, compound

HRID 1029794Notes

Reaction equation

HRID 1029794 reaction equation
[S:1]1[CH2:4][S:3][C:2]1=[C:5]([C:12](C(OOCC)=O)=[O:13])[C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7].[CH2:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)Cl>[S:3]1[CH2:4][S:1][C:2]1=[C:5]([C:12](=[O:13])[NH:27][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:6]([O:8][CH:9]([CH3:10])[CH3:11])=[O:7]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 19901120HCID 19901120, compound

Product 1

HCID 19901141HCID 19901141, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The mixture of isopropyl 2-(1,3-dithietan-2-ylidene)-2-(ethoxycarboxycarbonyl)acetate (15 g) and benzylamine (6.4 ml) in methylene chloride (150 ml) was stirred at room temperature for 4 hrs. The reaction mixture was then washed with dil-HCl and water to remove benzylamine. The solvent was evaporated and the residue was purified with ethyl acetate to give the titled compound as a white solid. (12.2 g, 77%).

Workup

  1. washThe reaction mixture was then washed with dil-HCl and water
  2. customto remove benzylamine
  3. customThe solvent was evaporated
  4. customthe residue was purified with ethyl acetate

Sources & evidence

ORD record
ord-5dd5942467bc42828d95c8cc8c35b5d9
Source dataset
uspto-grants-1992_04
Patent number
US05103013

Reaction notes

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