2-Aminothiazole → HCID 9883408, compound

Participants

Reaction Steps

The solution of isopropyl 2-(1,3-dithietan-2-ylidene)-2-(ethoxycarboxycarbonyl)acetate (10 g) and 2-aminothiazole (4.0 g) in methylene chloride (100 ml) was stirred at room temperature for 24 hrs. The reaction mixture was washed with 10% aqueous sodium hydroxide solution and water and then evaporated. The residue was chromatographed on silica gel column using methylene chloride as an eluent to afford the titled compound as a white solid (6.5 g, 63%).

Provenance & Evidence