反应详情

1000 g of formic acid were introduced into a flask fitted with a stirrer and a reflux condenser. 151 g (1 mol) of 2-methyl-4-nitroaniline were added, and the resultant mixture was slowly heated to the reflux point. After four hours, the reaction mixture was poured into 5 l of ice water. The resultant precipitate was filtered off with suction, washed with water until neutral and then dried at 60° C. under reduced pressure. Recrystallization of the resultant crude product from 2.5 l of methanol or ethanol gave 171 g of N-formyl-2-methyl-4-nitroaniline (yield: 95%) as yellow crystals, which melted at 162° C.

1. customfitted with a stirrer and a reflux condenser
2. filtrationThe resultant precipitate was filtered off with suction
3. washwashed with water until neutral and
4. customthen dried at 60° C. under reduced pressure
5. customRecrystallization of the resultant crude product from 2.5 l of methanol or ethanol