Hydrochloric Acid → HCID 67915940, compound

Participants

Reaction Steps

(3aRS,7aRS)-2-[(2-tert-butoxycarbonylaminophenyl)acetyl]-7,7-diphenyl-4-perhydroisoindolone (1.5 g) is treated with a 5.7N solution (15 cc) of hydrochloric acid in dry dioxane at 20° C. for 4 hours. The reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) and the residue is purified by dissolving in acetonitrile (20 cc) and precipitating from isopropyl ether (30 cc). The solid is drained, washed with isopropyl ether and dried. (3aRS,7aRS)-2-[(2-aminophenyl)acetyl]-7,7-diphenyl-4-perhydroisoindolone hydrochloride (1.1 g) is obtained in the form of a slightly pink solid.

Provenance & Evidence