HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (3aRS,7aRS)-7,7-Diphenylperhydro-4-isoindolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7,7-Diphenylhexahydro-1H-isoindol-4(2H)-one hydrochloride | HCID 21264543 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3aRS,7aRS)-7,7-Diphenylperhydro-4-isoindolone | HCID 21264544 | 88.1% |
Reaction Steps
4N aqueous sodium hydroxide solution (100 cc) is added to a solution of (3aRS,7aRS)-7,7-diphenyl-4-perhydroisoindolone hydrochloride (16.6 g) in dichloromethane (250 cc), with stirring; the organic phase is dried over magnesium sulphate and filtered and the filtrate is concentrated to dryness under reduced pressure (4 kPa). (3aRS,7aRS)-7,7-diphenyl-4-perhydroisoindolone (13 g) is obtained in the form of a white meringue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102667 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-d5466c0e48df40dda68daa492f1d73ff |
| Source note | uspto-grants-1992_04 |