Hydrochloric Acid → HCID 22843232, compound

Participants

Reaction Steps

A solution of (3aR,7aR)-2-[(S)-2-acetoxy-2-phenylacetyl]-7,7-diphenyl-4-perhydroisoindolone (2 g) in a mixture of water (20 cc) and ethanol (25 cc) is treated with normal sodium hydroxide solution (5 cc) and the mixture is refluxed for 1 hour, then diluted with water (100 cc) and ethyl acetate (50 cc) and neutralized by the addition of normal hydrochloric acid (5 cc). The organic phase is washed with water (50 cc) and with a saturated sodium chloride solution (50 cc), dried over magnesium sulphate and concentrated to dryness under reduced pressure (2.7 kPa) to give (3aR,7aR)-2-[(S)-2-hydroxy-2-phenylacetyl]-7,7-diphenyl-4-perhydroisoindolone (1.3 g) in the form of a white meringue.

Provenance & Evidence