Ethyl Acetate → HCID 54374521, compound

Participants

Reaction Steps

A solution of 1,1-bis-(3-chlorophenyl)-2-methoxyethanol (47 g) (obtained by reaction of (3-chlorophenyl)magnesium bromide on methyl 2-methoxyacetate in tetrahydrofuran) in formic acid (44 cc) is refluxed for 5 hours, cooled and poured into a mixture of saturated sodium carbonate solution (500 cc) and ethyl acetate (300 cc). The organic phase is washed with water (3×250 cc) and with saturated sodium chloride solution (200 cc), then dried and concentrated to dryness under reduced pressure (2.7 kPa) to give bis-(3-chlorophenyl)acetaldehyde (36.9 g) in the form of a yellow oil.

Provenance & Evidence